Why RUCONEST?
Treat your HAE with confidence.
Peggy, RUCONEST patient
When HAE attacks happen, you need a
treatment you can count on.
If you are treating the same swell multiple times, speak to your doctor about a change. RUCONEST is a C1 esterase inhibitor, or C1-INH, indicated for the treatment of acute attacks in adult and adolescent patients with HAE. It replaces the missing or nonworking C1-INH to stop an HAE swell before it fully develops.
Reliable
97% of acute attacks needed just one dose of RUCONEST*
~9 of 10 patients achieved symptom relief with just one dose of RUCONEST at 50 U/kg (n=44) in the primary clinical study
In the primary clinical study, patients saw symptom relief in 90 minutes vs 152 minutes with placebo
In the extension study, symptom relief began in 75 minutes11
Rapid and Complete Attack Resolution
Median time to complete attack resolution†
Reliable
Stopped 93% of attacks for at least 3 days‡
* 50 U/kg (max 4200 U) in clinical studies (open-label extension phase, n=44 [170 swells]).
† Based on post hoc analysis of pooled data including 108 patients across 3 RCTs evaluating RUCONEST (RUCONEST arm, n=48, 50 U/kg [max 4200 U]; placebo arm, n=60). Time to complete attack resolution was defined as a PGI-S category of “none” within 24 h of treatment administration. A bookmarking study was used to map VAS scores from the original RUCONEST RCTs to the corresponding PGI-S category.
‡ Based on a post hoc analysis of pooled data from the randomized controlled study and open-label extension phases of 2 studies involving 127 patients aged ≥12 years who were treated with RUCONEST 50 U/kg (max 4200 U) for acute swells of HAE. Data for 72 hours were available for 68 of 127 patients (280 swells).
Real stories. Real confidence.
Tequoia on Why RUCONEST: Showing up for the people she loves.
RUCONEST is well-tolerated
RUCONEST has a well-established tolerability profile. Adverse reactions in ≥2% of patients in 7 studies (all RUCONEST doses up to 100 U/kg) included:
Headaches
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