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RUCONEST Treatment for HAE Attacks
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IMPORTANT SAFETY INFORMATION

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WHAT IS RUCONEST?

RUCONEST® (C1 esterase inhibitor [recombinant]) is an injectable prescription medicine that is used to treat swelling and/or painful attacks due to hereditary angioedema (HAE) in adult and adolescent patients over the age of 12.

Do not use RUCONEST if you have experienced life-threatening immediate hypersensitivity reactions, including anaphylaxis, to  RUCONEST or to any other C1 esterase inhibitor (C1-INH) product. Call your healthcare professional or the emergency department right away if you experience: wheezing, difficulty breathing, chest tightness, turning blue (look at lips and gums), fast heartbeat, swelling, faintness, rash or hives. A serious side effect of life-threatening hypersensitivity (anaphylaxis) was reported in a clinical study.

WHAT IS RUCONEST?

RUCONEST® (C1 esterase inhibitor [recombinant]) is an injectable prescription medicine that is used to treat swelling and/or painful attacks due to hereditary angioedema (HAE) in adult and adolescent patients over the age of 12.

Do not use RUCONEST if you have experienced life-threatening immediate hypersensitivity reactions, including anaphylaxis, to  RUCONEST or to any other C1 esterase inhibitor (C1-INH) product. Call your healthcare professional or the emergency department right away if you experience: wheezing, difficulty breathing, chest tightness, turning blue (look at lips and gums), fast heartbeat, swelling, faintness, rash or hives. A serious side effect of life-threatening hypersensitivity (anaphylaxis) was reported in a clinical study.  

Do not use RUCONEST if you have a known or suspected allergy to rabbits or rabbit-derived products. Tell your healthcare provider about all your medical conditions, including if you have a known allergy to rabbits. Before starting RUCONEST, tell your healthcare provider about any other medications you are taking, as some medications, such as birth control pills and certain androgens, can increase risk of clotting problems. Blood clots have occurred in patients receiving plasma-derived C1-INH product. Also tell your healthcare provider if you are pregnant, breastfeeding, or planning to do so.  

The most common side effects patients experienced during clinical studies include headache, nausea and diarrhea. These are not all the possible side effects of RUCONEST. Tell your healthcare provider about any side effect that bothers you or does not go away. You can also report negative side effects to Pharming Medical Affairs at (800) 930-5221, or contact the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.  

If symptoms persist, a second dose of RUCONEST may be taken at your recommended dose. Do not take more than two doses within 24 hours.  

For more information, please see the full Prescribing Information including the Patient Product Information.

WHAT IS RUCONEST?

RUCONEST® (C1 esterase inhibitor [recombinant]) is an injectable prescription medicine that is used to treat swelling and/or painful attacks due to hereditary angioedema (HAE) in adult and adolescent patients over the age of 12.

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RUCONEST is a registered trademark of Pharming Intellectual Property, B.V.
© 2026 Pharming Healthcare, Inc. | RUC-US-2021-0238v11
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Some insurance companies are instituting new policies called accumulator adjustment programs and/or maximizer programs. These can affect your participation in the RUCONEST Patient Savings Program.
  • Accumulator Adjustment Programs are when your insurance plan does not apply the RUCONEST Patient Savings Program to satisfy your co-payment, deductible, or co-insurance for RUCONEST.
  • Co-pay Maximizer Programs are when your insurance company requires you to enroll in the RUCONEST Patient Savings Program as a condition of your plan or to waive other costs associated with the insurance plan.
  • If your plan has these limitations, you will not be eligible for the RUCONEST Patient Savings Program, but you may be eligible for other external needs-based assistance programs. Please contact RUCONEST SOLUTIONS for additional information.
If you have any questions, our team of experts is available to provide assistance. Our priority is your well-being. Please call RUCONEST SOLUTIONS for more information at 1-855-613-4HAE (4423).

*Program Disclaimer Your Patient Consent form is required before you can access RUCONEST SOLUTIONS support services, which includes Starter Rx and access to an RPA.

Some programs are limited to patients with commercial insurance.

The program only applies in the United States, including Puerto Rico and other US territories, and does not apply where prohibited by state law or other restrictions. Program is subject to availability, and Pharming Healthcare, Inc., reserves the right to rescind, revoke or amend the Program at any time without notice.

If your insurance company is impacted by an Accumulator and/or a Maximizer program, this can impact program eligibility. 

Some insurance companies are instituting new policies called accumulator adjustment programs and/or maximizer programs. These can affect your participation in the RUCONEST Patient Savings Program.

  • Accumulator Adjustment Programs are when your insurance plan does not apply the RUCONEST Patient Savings Program to satisfy your co-payment, deductible, or co-insurance for RUCONEST.
  • Co-pay Maximizer Programs are when your insurance company requires you to enroll in the RUCONEST Patient Savings Program as a condition of your plan or to waive other costs associated with the insurance plan.
  • If your plan has these limitations, you will not be eligible for the RUCONEST Patient Savings Program, but you may be eligible for other external needs-based assistance programs. Please contact Ruconest Solutions for additional information.
If you have any questions, our team of experts is available to provide assistance. Our priority is your well-being. Please call Ruconest Solutions for more information at 1-855-613-4HAE (4423).

‡Terms and Conditions Patients new to RUCONEST may be eligible for a free trial (up to 2 doses). Free trial offer is subject to modification or cancellation at any time, with or without notice. Program is subject to eligibility restrictions and is good for only one StarterRx offer per lifetime. Diversion Program or company mandates that you apply, maximize, exhaust, and/or show proof of denial in a manufacturing's assistance program, you are not eligible for Pharming's Patient Assistance Program even if you meet all other coverage criteria. Pharming Healthcare, Inc., does not have any obligation to provide the program services to you and is not liable in the provision of these services. If you do not have insurance or insurance for RUCONEST, we may be able to help you find a program that fits based on eligibility or availability. Before you enroll in the Patient Assistance Program, it is important you understand that you will be asked to provide personal information that may include your name, address, phone number, email address, financial information, and information related to your prescription medication insurance and treatment. This information will be used by Pharming Healthcare, Inc., and its service providers to determine your eligibility for, enroll you in, and administer the program. Offer good only in the United States and its territories. Void where prohibited, taxed, or limited by law. Program terms will expire at the end of each calendar year and may change or end without notice, including in specific states. Some employers, insurers, and other companies require patients to apply for medication coverage from free product programs instead of covering such medications directly and immediately through insurance, which could lead to delays in care. These types of “Assistance Diversion Programs” are generally established by companies that profit by diverting resources away from patients in need. An Assistance Diversion Program is any insurer, employer, or third-party program that withholds coverage or payment for patient's medically necessary drug until patient has completed an application for free productassistance. If your employer, insurer, or any other Assistance Diversion Program or company mandates that you apply, maximize, exhaust, and/or show proof of denial in a manufacturing's assistance program, you are not eligible for Pharming's Patient Assistance Program even if you meet all other coverage criteria. Pharming Healthcare, Inc., does not have any obligation to provide the program services to you and is not liable in the provision of these services.

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